During the development of anti-inflammatory therapies immune-boosting vaccines, immunoassays for T-cells, dendritic cells, and mast cells are key tools for understanding the mechanisms of action, efficacy, and safety of these innovative therapeutics.
At Marinomed, we can support your research and development efforts by utilizing immunoassays to test and evaluate the immune-modulating properties, inflammation control, and antigen presentation of your novel APIs.
By working with us, you will gain a deeper understanding of how your novel API or formulation may interact with the immune system and how it can be optimized to effectively treat autoimmune disorders, allergies, infections, or support cancer immunotherapy and vaccination strategies, or prove safe for use in products that should not affect immune function.
If your API is designed to downregulate inflammation or modulate immune responses, we can help assess its effects using T-cell, and dendritic cell assays. These assays can evaluate how your product influences key immune processes like Cytokine release, T-cell activation, NF-kB pathway. Allowing you to determine how well it might control chronic inflammation, autoimmunity or allergic reactions.
If your product aims to enhance antigen expression, we use dendritic cell assays to evaluate its ability to stimulate an immune response. We will help you understand how your API interacts with dendritic cells to present antigens and activate T-cells, providing you with early insights into the potential success of your vaccine or immunotherapy in fighting infection, cancer or other immune-related conditions.
As part of our toxicity studies, we offer a decongestion assay to assess the effects of substances on cellular structures. Using Flow cytometry (FACS), we analyze changes in cell size, which can be indicative of cellular stress, swelling, or damage. This assay is useful for evaluating how a test compound may influence cellular integrity, inflammation or other toxicity related processes.
Mast cells play a critical role in allergic reactions, and testing your product for its interaction with mast cells can help assess safety and efficacy in preventing or mitigating allergic responses. If your product is designed to treat allergies or reduce hypersensitivity, we offer specialized assays to evaluate mast cell activation and degranulation. By evaluating how your API interacts with mast cells, we can determine its potential to modulate allergic responses and prevent pr treat allergic reactions. In addition to histamine release, we can measure the production of various cytokines (e.g., Il-4, TNF-alpha, and others) that are involved in the allergic inflammatory response. This will help you understand how your API might influence allergic pathways.
